Move a profile to Portable Thunderbird
From MozillaZine Knowledge Base
Portable Thunderbird is a third party build of Mozilla Thunderbird that includes a launcher to let you store your profile on the USB drive, along with Portable Thunderbird.
Your profile stores your email, address books, settings, add-ons and saved passwords. Thunderbird normally finds it by looking in a profiles.ini file on your boot drive. You can have multiple profiles, the file also tells Thunderbird which one to use by default. Portable Thunderbird only supports one profile, which it expects to find in the Data\profile directory within Thunderbird Portable. If you're switching to Portable Thunderbird you just have to find your current profile and copy its contents there . Don't copy the actual directory too.
Recent versions of Thunderbird will open windows explorer (or your operating system's equivalent) showing the profile directory if you press the "show folder" button in help -> troubleshooting information. Otherwise see this article for how to find your profile under Windows.
If this doesn't work:
The Portable Thunderbird web page states it supports Windows XP and later versions of Windows, and running under Linux/UNIX using Wine. The Wine application database gives Portable Thunderbird a platinum rating. A platinum rating is assigned to "Applications which install and run flawlessly on an out-of-the-box Wine installation". If for some reason you don't want to use Wine you could use the normal version of Thunderbird and pass it the profiles location as a command line argument.