From MozillaZine Knowledge Base
You can create a new account by pressing the Add Mail Account button in Tools -> Account Settings -> Account Actions. All you need to know is your email address and password, it will configure the account settings for you. It defaults to a IMAP account but you can tell it to use a POP account instead using a radio button. If you don't want it to automatically configure your account press the "Manual Config" button in the second screen of "Mail Account Setup".
After you create the POP/IMAP account in Thunderbird enable using the POP or IMAP server with your account by:
If you're using the same Gmail POP account with multiple email clients you need to enable recent mode in order to let each email client access all of the messages in that account. You can do that by replacing email@example.com with recent:firstname.lastname@example.org as the username in Tools -> Account Settings -> Server Settings.
The account wizard uses googlemail.com instead of gmail.com in the server names. They're equivalent. Gmail is rebranded as Google Mail in Germany, Austria and the United Kingdom.
Set tools -> account settings -> server settings -> advanced -> IMAP server directory to [Gmail] to fix problems with how it lists folders in the folder pane.
Don't configure Thunderbird to save a copy of any messages you send in tools -> account settings -> copies & folders. Gmail's SMTP server automatically saves a copy of any message you send in the Sent Items folder for you.
The SMTP server also supports using port 465 with SSL/TLS. 
Subscriptions control whether an IMAP folder is visible in the folder pane (and any lists of folders). If it is cluttered with folders you don't normally use, you might want to hide some by unsubscribing them. You won't be notified of new mail in unsubscribed folders.
You can subscribe or unsubscribe a folder by:
You can also use the Subscribe and Unsubscribe buttons in that menu.
Gmail IMAP accounts have a All Mail folder which contains a copy of every message. This is an artifact of how Gmail implemented labels, not a Thunderbird quirk. That folder is also used as the archive folder.
Tools -> Account Settings -> Gmail -> Synchronization & Storage -> Advanced is configured to keep a local copy of all IMAP folders on your hard disk. The All Mail folder doubles the amount of disk space used by your Gmail account and may cause some problems. It is recommended that you remove it. The safe way to do that is:
If you have multiple Gmail IMAP accounts some of the directories will have a numeric prefix such as imap.gmail-1.com. Look at the "Local Directory" setting at the bottom of the Tools -> Account Settings -> account_name -> Server Settings (by the browse button) to find the name of that account's directory.
Troubleshooting and Gmail quirks
Gmail treats POP and IMAP messages individually and not as a threaded conversation.
The IMAP support is buggy/incomplete, though it's improved a lot since it was first available.
The IMAP folders correspond to the labels in Gmail's webmail. IMAP folder hierarchy is represented by "/" in Gmail's label. e.g. IMAP subfolder XYZ under ABC is mapped to label of ABC/XYZ(maximum length=40 bytes). However, mapping of IMAP folder to Gmail's folder or label at Web interface is special on some special folders.
If you look at the All Mail folder([Gmail]/All Mail of IMAP) using Gmails webmail it will label any IMAP messages with the name of the folder. If you delete a message in Thunderbird it simply removes that folder's label from the message. Compacting the folder doesn't remove the message from the All Mail folder([Gmail]/All Mail of IMAP). You need to move it to the Trash or Spam folder([Gmail]/All Mail or [Gmail]/Spam of IMAP) to delete the message from all folders. It's not clear yet if this is also true for Message aging. Moving back of mail in [Gmail]/All Mail of IMAP to any IMAP mail folder(except [Gmail]/Spam) restores all Gmail's label.
A single copy of each message is stored in the account, and if the messages has multiple labels there are pointers to that copy, a change introduced in version 17.0.2 by bug 721316. (Prior to version 17.0.2 a copy of a message is stored for each label. That means if you assign two labels to a message and star it using Gmails webmail it has a copy in two folders named after the label, the All Mail folder, and the Starred folder.) If you copy a message to multiple remote folders (using Thunderbird) it will be marked with the corresponding labels when viewed using Gmail webmail.
If you move a message into the Spam folder, it is treated the same as if you had reported it in Gmail webmail using 'Report Spam'. See How do actions sync in IMAP? on Gmails web site for more information on how it maps things.
Gmail recommends that you do not use [Gmail]/Trash as your Trash folder since Gmail only keeps a single copy of a message with multiple labels. If you delete a message that way you're also telling it to delete the same message from any other folder (label) that has that message.  Gmail recommends not making Thunderbird move deleted mail into any folder and instead choose "Just mark it as deleted" from "When I delete a message" in Account Settings -> Server Settings.
Gmail supports plus-addressing, a useful way to create a disposable email address. Let's say your email address is JohnSmith@gmail.com and you need to give the xyzzy website an email address. If you give them JohnSmithemail@example.com, it will still be delivered to your inbox, despite the To: header having an extra "+xyzzy". If somebody starts sending spam to that email address, you could create a message filter that tests for xyzzy in the To: header and automatically delete (or move to the Junk mail folder) those messages when checking for new mail. Some email systems violate RFC 2822 and won't send a message using plus addressing, but it is normally not a problem.
Gmail supports a way to periodically fetch email from up to five POP accounts and merge them into your inbox. The POP accounts could be provided by Gmail or another email provider. It works with Thunderbird, but you have to configure mail fetcherusing Gmail webmail.
Two step verification
The Google Account help advocates using two step authentication. That sends a code (a minimum of once a month but ideally every time you log in) to your cell phone that you need to enter when logging in using a browser. However applications such as email clients can't do that. If you configure two step verification you need to create an application specific password for Thunderbird that you use instead of the normal password. The application specific password doesn't change when a new code is sent to your cell phone.
Two step verification is not needed, and not recommended. Use a strong password, and don't use the same password with other email providers/web sites, instead. However, if you have another email account it is a good idea to set a recovery email address in case you ever forget/lose your password.
Gmail supports the CardDAV protocol (an address book client/server protocol designed to allow users to access and share contact data on a server). Currently the SoGo connector add-on is the best way to add CardDav support to Thunderbird. However, it has a reputation as being buggy and having poor support. There is a bug report requesting built-in support for CardDAV. The address book is being completely redesigned and will include support for multiple contact providers. Based on this blog post it looks like that will eventually include support for CardDAV. See this forum thread for information on other alternatives.
Gmail does not provide a LDAP server. LDAP is another protocol to access contact data. Thunderbird has built-in support for creating an address book that uses a LDAP server, but no support for modifying its contacts. You used to be able to use GCALDaemon to provide a the equivalent of a Gmail LDAP server, but it used the deprecated GData API, and doesn't work anymore.
This bug effects other email providers but is most frequently reported for Gmail.